The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression

Abstract Eukaryotic initiation translation factor 3 subunit h (EIF3H) plays critical roles in regulating translational initiation and predicts poor cancer prognosis, but the mechanism underlying EIF3H tumorigenesis remains to be further elucidated. Here, we report that EIF3H is overexpressed in colo...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Huilin Jin, Xiaoling Huang, Qihao Pan, Ning Ma, Xiaoshan Xie, Yue Wei, Fenghai Yu, Weijie Wen, Boyu Zhang, Peng Zhang, Xijie Chen, Jie Wang, Ran-yi Liu, Junzhong Lin, Xiangqi Meng, Mong-Hong Lee
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-03-01
Online Access:	https://doi.org/10.1038/s41467-024-46521-3