Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis

Abstract Liver metastasis remains the primary cause of mortality in patients with colon cancer. Identifying specific driver gene mutations that contribute to metastasis may offer viable therapeutic targets. To explore clonal evolution and genetic heterogeneity within the metastasis, we conducted sin...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Signal Transduction and Targeted Therapy
المؤلفون الرئيسيون:	Jianqiang Cai, Weilong Zhang, Yalan Lu, Wenjie Liu, Haitao Zhou, Mei Liu, Xinyu Bi, Jianmei Liu, Jinghua Chen, Yanjiang Yin, Yiqiao Deng, Zhiwen Luo, Yi Yang, Qichen Chen, Xiao Chen, Zheng Xu, Yueyang Zhang, Chaoling Wu, Qizhao Long, Chunyuan Huang, Changjian Yan, Yan Liu, Lei Guo, Weihua Li, Pei Yuan, Yucheng Jiao, Wei Song, Xiaobing Wang, Zhen Huang, Jianming Ying, Hong Zhao
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Nature Publishing Group 2024-09-01
الوصول للمادة أونلاين:	https://doi.org/10.1038/s41392-024-01960-8