Effect of primary structural variation on cervid prion protein in flexibility, stability, and spontaneous misfolding propensity

Protein misfolding is central to numerous neurodegenerative disorders, collectively known as proteinopathies, which include Alzheimer's disease, Parkinson's disease, and prion diseases, among others. In many cases, specific polymorphisms of the proteins associated with these diseases influ...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Carlos M. Díaz-Domínguez, Hasier Eraña, Francesca Peccati, Enric Vidal, Jorge M. Charco, Cristina Sampedro-Torres-Quevedo, Miguel A. Pérez-Castro, Nuria L. Lorenzo, Samanta Giler, Glenn C. Telling, Mariví Geijo, Jesús R. Requena, Gonzalo Jiménez-Osés, Joaquín Castilla
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Subjects:	CWD Misfolding Polymorphisms Prion Proteinopathy Stability
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996125002219