FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity

Summary: The mechanical environment generated through the adhesive interaction of endothelial cells (ECs) with the matrix controls nuclear tension, preventing aberrant gene synthesis and the transition from restrictive to leaky endothelium, a hallmark of acute lung injury (ALI). However, the mechani...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Md Zahid Akhter, Pascal Yazbeck, Mohammad Tauseef, Mumtaz Anwar, Faruk Hossen, Sayanti Datta, Vigneshwaran Vellingiri, Jagdish Chandra Joshi, Peter T. Toth, Nityanand Srivastava, Stephen Lenzini, Guangjin Zhou, James Lee, Mukesh K. Jain, Jae-Won Shin, Dolly Mehta
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	CP: Cell biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124724006259