A pragmatic, multicenter, randomized trial comparing morning versus evening dosing of adjuvant endocrine therapy (REaCT-CHRONO Study)

Abstract The time of day of administration (chronotherapy) of certain medications can affect both their toxicity and efficacy. In this pragmatic, multicenter trial, women starting adjuvant endocrine therapy (ET) for hormone receptor-positive early-stage breast cancer were randomized (1:1) to either...

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Bibliographic Details

Published in:	npj Breast Cancer
Main Authors:	M. F. Savard, M. Ibrahim, D. Saunders, G. R. Pond, T. L. Ng, A. A. Awan, S. Sehdev, N. Alqahtani, L. Vandermeer, F. MacDonald, A. A. Beltran-Bless, L. Fallowfield, M. Clemons
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Online Access:	https://doi.org/10.1038/s41523-025-00762-7