Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways

Although long-term survival in pediatric acute lymphoblastic leukemia (ALL) currently exceeds 90%, some subgroups, defined by specific genomic aberrations, respond poorly to treatment. We previously reported that leukemias harboring deletions or mutations affecting the B-cell transcription factor IK...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Miriam Butler, Britt M.T. Vervoort, Dorette S. van Ingen Schenau, Lieneke Jongeneel, Jordy C.G. van der Zwet, René Marke, Jules P.P. Meijerink, Blanca Scheijen, Laurens T. van der Meer, Frank N. van Leeuwen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Subjects:	leukemia glucocorticoids IKZF1 therapy resistance AKT ERK
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.905665/full