An integrated approach for analyzing spatially resolved multi-omics datasets from the same tissue section

Recent advances in spatial transcriptomics (ST) and spatial proteomics (SP) technologies have enabled high-dimensional molecular profiling at single-cell resolution, providing deeper insights into the tumour-immune microenvironment. However, these modalities are typically applied to separate tissue...

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Bibliographic Details

Published in:	Frontiers in Molecular Biosciences
Main Authors:	Thao Tran, Felicia Wee, Craig Ryan Joseph, Wanqiu Zhang, Jeffrey Chun Tatt Lim, Zhen Wei Neo, Li Yen Chong, Francis Hong Xin Yap, Nathan Heath Patterson, Marc Claesen, Alice Ly, Joe Yeong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Subjects:	spatial multi-omics image registration single cell analysis spatial transcriptomics spatial proteomics histology
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2025.1614288/full