Simulating BRAFV600E-MEK-ERK signalling dynamics in response to vertical inhibition treatment strategies

Abstract In vertical inhibition treatment strategies, multiple components of an intracellular pathway are simultaneously inhibited. Vertical inhibition of the BRAFV600E–MEK-ERK signalling pathway is a standard of care for treating BRAFV600E-mutated melanoma where two targeted cancer drugs, a BRAFV60...

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Bibliographic Details

Published in:	npj Systems Biology and Applications
Main Authors:	Alice De Carli, Yury Kapelyukh, Jochen Kursawe, Mark A. J. Chaplain, C. Roland Wolf, Sara Hamis
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-05-01
Online Access:	https://doi.org/10.1038/s41540-024-00379-9