Effect and mechanism of PYCR1 on biological function of hepatocellular carcinoma cells under hypoxia

Abstract Background Pyrrole-5-carboxylate reductase 1 (PYCR1) is a key enzyme involved in proline synthesis, which is closely related to the occurrence and development of liver cancer. In this study, we aimed to investigate the relationship and mechanism of PYCR1 on proline metabolism in hepatocellu...

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Bibliographic Details
Published in:Discover Oncology
Main Authors: Jiayi Guo, Xinxin Jin, Junli Zhang, Yuming Zhang, Wenjuan Wu
Format: Article
Language:English
Published: Springer 2025-06-01
Subjects:
Liver cancer
PYCR1
Hypoxia
Metabolism
Proliferation
Online Access:https://doi.org/10.1007/s12672-025-03028-7

Internet

https://doi.org/10.1007/s12672-025-03028-7

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