Enhancing Single-Cell and Bulk Hi-C Data Using a Generative Transformer Model

The 3D organization of chromatin in the nucleus plays a critical role in regulating gene expression and maintaining cellular functions in eukaryotic cells. High-throughput chromosome conformation capture (Hi-C) and its derivative technologies have been developed to map genome-wide chromatin interact...

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Bibliographic Details

Published in:	Biology
Main Authors:	Ruoying Gao, Thomas N. Ferraro, Liang Chen, Shaoqiang Zhang, Yong Chen
Format:	Article
Language:	English
Published:	MDPI AG 2025-03-01
Subjects:	Hi-C scHi-C data imputation transformer model deep learning
Online Access:	https://www.mdpi.com/2079-7737/14/3/288