Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma

Abstract Thrombocytopenia is a major complication in a subset of patients with multiple myeloma (MM). However, little is known about its development and significance during MM. Here, we show thrombocytopenia is linked to poor prognosis in MM. In addition, we identify serine, which is released from M...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Chunmei Kuang, Meijuan Xia, Gang An, CuiCui Liu, Cong Hu, Jingyu Zhang, Zhenhao Liu, Bin Meng, Pei Su, Jiliang Xia, Jiaojiao Guo, Yinghong Zhu, Xing Liu, Xuan Wu, Yi Shen, Xiangling Feng, Yanjuan He, Jian Li, Lugui Qiu, Jiaxi Zhou, Wen Zhou
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-04-01
Online Access:	https://doi.org/10.1038/s41467-023-37699-z