Cancer burden in individuals with single versus double pathogenic variants in cancer susceptibility genes

Purpose: As panel testing expands, more individuals with double pathogenic variants (DPVs) in cancer susceptibility genes are likely to be identified. Little is known about the effects of DPVs on cancer phenotype, although this information is crucial for genetic counseling and risk management. We so...

Full description

Bibliographic Details

Published in:	Genetics in Medicine Open
Main Authors:	Nihat B. Agaoglu, Brittany L. Bychkovsky, Carolyn Horton, Min-Tzu Lo, Linda Polfus, Cassidy Carraway, Parichehr Hemyari, Colin Young, Marcy E. Richardson, Rochelle Scheib, Judy E. Garber, Huma Q. Rana
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Subjects:	Breast cancer Genetics Germline Hereditary cancer Multiple pathogenic variants
Online Access:	http://www.sciencedirect.com/science/article/pii/S2949774424009750