Identification of anti-citrullinated osteopontin antibodies and increased inflammatory response by enhancement of osteopontin binding to fibroblast-like synoviocytes in rheumatoid arthritis

Abstract Background Anti-citrullinated protein/peptide antibodies (ACPAs) are present in patients at onset and have important pathogenic roles during the course of rheumatoid arthritis (RA). The characteristics of several molecules recognized by ACPA have been studied in RA, but the positivity rate...

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Bibliographic Details

Published in:	Arthritis Research & Therapy
Main Authors:	Akio Umemoto, Takeshi Kuwada, Koichi Murata, Masahiro Shiokawa, Sakiko Ota, Yoshiki Murotani, Akihiro Itamoto, Kohei Nishitani, Hiroyuki Yoshitomi, Takayuki Fujii, Akira Onishi, Hideo Onizawa, Kosaku Murakami, Masao Tanaka, Hiromu Ito, Hiroshi Seno, Akio Morinobu, Shuichi Matsuda
Format:	Article
Language:	English
Published:	BMC 2023-02-01
Subjects:	Rheumatoid arthritis Anti-citrullinated protein antibody Osteopontin Citrullination Integrin
Online Access:	https://doi.org/10.1186/s13075-023-03007-9