Role of prolyl hydroxylase domain proteins in bone metabolism

Cellular metabolism requires dissolved oxygen gas. Because evolutionary refinements have constrained mammalian dissolved oxygen levels, intracellular oxygen sensors are vital for optimizing the bioenergetic and biosynthetic use of dissolved oxygen. Prolyl hydroxylase domain (PHD) homologs 1–3 (PHD1/...

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Bibliographic Details

Published in:	Osteoporosis and Sarcopenia
Main Authors:	David Wolf, Aruljothi Muralidharan, Subburaman Mohan
Format:	Article
Language:	English
Published:	Elsevier 2022-03-01
Subjects:	Bone Prolyl hydroxylase domain Hypoxia-inducible factor Bone regeneration Oxygen sensor Epigenetic regulation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405525522000036