Effect of Decorin and Aligned Collagen Fibril Topography on TGF-β1 Activation of Corneal Keratocytes

During corneal wound healing, transforming growth factor-beta 1 (TGF-β1) causes differentiation of quiescent keratocytes into myofibroblasts. Decorin has been investigated as a promising anti-fibrotic therapeutic for corneal healing due to its interaction with TGF-β1, collagen, and cell surface rece...

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發表在:	Bioengineering
Main Authors:	Nathaniel S. Tjahjono, Divya Subramanian, Tarik Z. Shihabeddin, Hudson D. Hicks, Victor D. Varner, W. Matthew Petroll, David W. Schmidtke
格式:	Article
語言:	英语
出版:	MDPI AG 2025-03-01
主題:	decorin aligned collagen fibrils corneal keratocytes transforming growth factor-beta alpha-smooth muscle actin
在線閱讀:	https://www.mdpi.com/2306-5354/12/3/259