Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of most common and deadliest malignancies. Celastrol (Cel), a natural product derived from the Tripterygium wilfordii plant, has been extensively researched for its potential effectiveness in fighting cancer. However, its clinical application has been hindered b...

Full description

Bibliographic Details

Published in:	Asian Journal of Pharmaceutical Sciences
Main Authors:	Piao Luo, Qian Zhang, Shuo Shen, Yehai An, Lixia Yuan, Yin-Kwan Wong, Sizhe Huang, Shaohui Huang, Jingnan Huang, Guangqing Cheng, Jiahang Tian, Yu Chen, Xiaoyong Zhang, Weiguang Li, Songqi He, Jigang Wang, Qingfeng Du
Format:	Article
Language:	English
Published:	Elsevier 2023-11-01
Subjects:	Celastrol VDAC2 Ferroptosis Apoptosis Hepatocellular carcinoma Liposomes
Online Access:	http://www.sciencedirect.com/science/article/pii/S1818087623001009