Higher frequency of peripheral blood CD103+CD8+ T cells with lower levels of PD-1 and TIGIT expression related to favorable outcomes in leukemia patients

BackgroundLeukemia is a prevalent pediatric life-threatening hematologic malignancy with a poor prognosis. Targeting immune checkpoints (ICs) to reverse T cell exhaustion is a potentially effective treatment for leukemia. Tissue resident memory T (TRM) cells have been found to predict the efficacy o...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Lian Liu, Wenpu Lai, Xiaoling Zhuo, Sihui Chen, Xiaodan Luo, Huo Tan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-09-01
Subjects:	leukemia T cell exhaustion immune checkpoints tissue resident memory T cells CD103+CD8+ T cells PD-1
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1437726/full