ATP and Formyl Peptides Facilitate Chemoattractant Leukotriene-B4 Synthesis and Drive Calcium Fluxes, Which May Contribute to Neutrophil Swarming at Sites of Cell Damage and Pathogens Invasion

Here, we demonstrate that human neutrophil interaction with the bacterium <i>Salmonella typhimurium</i> fuels leukotriene B4 synthesis induced by the chemoattractant fMLP. In this work, we found that extracellular ATP (eATP), the amount of which increases sharply during tissue damage, ca...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Ekaterina A. Golenkina, Galina M. Viryasova, Svetlana I. Galkina, Iuliia V. Iakushkina, Tatjana V. Gaponova, Yulia M. Romanova, Galina F. Sud’ina
Format:	Article
Language:	English
Published:	MDPI AG 2024-05-01
Subjects:	neutrophil <i>Salmonella typhimurium</i> leukotriene B4 ATP intracellular calcium neutrophil swarming
Online Access:	https://www.mdpi.com/2227-9059/12/6/1184