Cellular targets and lysine selectivity of the HERC5 ISG15 ligase

Summary: ISG15 is a type I interferon-induced ubiquitin-like modifier that functions in innate immune responses. The major human ISG15 ligase is hHERC5, a ribosome-associated HECT E3 that broadly ISGylates proteins cotranslationally. Here, we characterized the hHERC5-dependent ISGylome and identifie...

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Bibliographic Details
Published in:iScience
Main Authors: Xu Zhao, Jessica M. Perez, Peter A. Faull, Catherine Chan, Femke W. Munting, Larissa A. Canadeo, Can Cenik, Jon M. Huibregtse
Format: Article
Language:English
Published: Elsevier 2024-02-01
Subjects:
Biochemistry
Molecular biology
Immunology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224000415

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http://www.sciencedirect.com/science/article/pii/S2589004224000415

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