Mutation of conserved MHC class I cytoplasmic tyrosine affects CD8+ T cell priming, effector function, and memory response

The cytoplasmic domain of MHC class I (MHC-I) molecules contains a single, highly conserved tyrosine residue (Y320). In previous work, we found that mice expressing a Y320F-mutated form of H-2Kb had reduced capacity to generate Kb-restricted cytotoxic T lymphocyte (CTL) responses following viral inf...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Yimo Sun, Yitao Tang, Priscilla Ortiz, Barbara Nassif Rausseo, Barbara Pazdrak, Lama Elzohary, Arjun Katailiha, Amjad Talukder, Cassian Yee, Richard Eric Davis, Gregory Lizée
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	MHC class I human leukocyte antigen (HLA) cytotoxic T cells dendritic cells tyrosine phosphorylation cytoplasmic tail
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1572342/full