Improving the therapeutic profile of MSCs: Cytokine priming reduces donor-dependent heterogeneity and enhances their immunomodulatory capacity

IntroductionMSCs exhibit regenerative, anti-inflammatory and immunomodulatory properties due to the large amount of cytokines, chemokines and growth factors they secrete. MSCs have been extensively evaluated in clinical trials, however, in some cases their therapeutic effects are variable. Therefore...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Jaris Valencia, Rosa M. Yáñez, Sandra Muntión, María Fernández-García, Jorge Diego Martín-Rufino, Agustín G. Zapata, Juan A. Bueren, Ángeles Vicente, Fermín Sánchez-Guijo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Subjects:	mesenchymal stem cells mesenchymal stromal cells MSCs cytokines priming heterogeneity
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1473788/full