Impact of microRNA polymorphisms on high-dose methotrexate-related hematological toxicities in pediatric acute lymphoblastic leukemia

ObjectivesIt is well known that transporter and enzyme genes could be regulated by microRNA (miRNA) at the post-transcriptional level, and single-nucleotide polymorphisms (SNPs) in miRNA, which are involved in the miRNA production and structure, may impact the miRNA expression level and then influen...

Full description

Bibliographic Details

Published in:	Frontiers in Pediatrics
Main Authors:	Min Zhan, Ting Liu, Zhou Zhang, Guoqiang Wang, Zhongqiang Cao, Xuejuan Li, Hongwu Zeng, Huirong Mai, Zebin Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Subjects:	acute lymphoblastic leukemia pediatric miRNA polymorphism methotrexate hematological toxicities
Online Access:	https://www.frontiersin.org/articles/10.3389/fped.2023.1153767/full