Orlistat Confers Neuroprotection in Traumatic Brain Injury by Modulating Microglial Lipid Metabolism

Traumatic brain injury (TBI) represents a major cause of mortality and disability worldwide, particularly affecting young adults and elderly populations. This study investigates the neuroprotective potential of orlistat (ORL), a gastrointestinal lipase inhibitor, in a murine TBI model. Behavioral, h...

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Bibliographic Details

Published in:	Cells
Main Authors:	Chenxuan Yu, Yu Ni, Yuxuan Xiong, Huayu Kang, Zhengqiao Jiang, Yuan Liu, Xincheng Zhang, Yanchao Liu, Kai Zhao, Sheng Wang, Chao Gan, Huaqiu Zhang
Format:	Article
Language:	English
Published:	MDPI AG 2025-09-01
Subjects:	TBI microglial orlistat LPL neuroinflammation
Online Access:	https://www.mdpi.com/2073-4409/14/18/1469