USP2 inhibition unleashes CD47-restrained phagocytosis and enhances anti-tumor immunity

Abstract The CD47/SIRPα axis conveys a ‘don’t eat me’ signal, thereby thwarting the phagocytic clearance of tumor cells. Although blocking antibodies targeting CD47 have demonstrated promising anti-tumor effects in preclinical models, clinical trials involving human cancer patients have not yielded...

Full description

Bibliographic Details

Published in:	Nature Communications
Main Authors:	Panpan Dai, Yishuang Sun, Zhengrong Huang, Yu-Tong Liu, Minling Gao, Hai-Ming Liu, Jie Shi, Chuan He, Bolin Xiang, Yingmeng Yao, Haisheng Yu, Gaoshan Xu, Lijun Kong, Xiangling Xiao, Xiyong Wang, Xue Zhang, Wenjun Xiong, Jing Hu, Dandan Lin, Bo Zhong, Gang Chen, Yan Gong, Conghua Xie, Jinfang Zhang
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Online Access:	https://doi.org/10.1038/s41467-025-59621-5