Protective Effect of Pyxinol, One Active Ingredient of Lichenes on Cisplatin-Induced Nephrotoxicity via Ameliorating DNA Damage Response

Background: Cisplatin is a valuable chemotherapeutic agent against malignant tumors. However, the clinical use of cisplatin is limited by its side effects such as renal injury. Pyxinol is an active constituent of Lichenes and its effects on cisplatin-induced nephrotoxicity is currently unknown. This...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Yanting Yang, Xiuhong Zhu, Guohua Yu, Jinbo Ma
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Subjects:	cisplatin nephrotoxicity pyxino DNA damage response p53 apoptosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.735731/full