Peroxisome proliferator-activated receptorα/γ agonist pioglitazone for rescuing relapsed or refractory neoplasias by unlocking phenotypic plasticity

A series of seven clinical trials on relapsed or refractory (r/r) metastatic neoplasias followed the question: Are networks of ligand-receptor cross-talks that support tumor-specific cancer hallmarks, druggable with tumor tissue editing approaches therapeutically exploiting tumor plasticity? Differe...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Dennis Christoph Harrer, Florian Lüke, Tobias Pukrop, Lina Ghibelli, Christopher Gerner, Albrecht Reichle, Daniel Heudobler
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-01-01
Subjects:	pioglitazone interferon-α dexamethasone all-trans retinoic acid tumor tissue editing anakoinosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1289222/full