Endocytic trafficking determines cellular tolerance of presynaptic opioid signaling

Opioid tolerance is well-described physiologically but its mechanistic basis remains incompletely understood. An important site of opioid action in vivo is the presynaptic terminal, where opioids inhibit transmitter release. This response characteristically resists desensitization over minutes yet b...

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Bibliographic Details

Published in:	eLife
Main Authors:	Damien Jullié, Camila Benitez, Tracy A Knight, Milos S Simic, Mark von Zastrow
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2022-11-01
Subjects:	GPCR opioid endocytosis axon neuron tolerance
Online Access:	https://elifesciences.org/articles/81298