Influence of Casein kinase II inhibitor CX-4945 on BCL6-mediated apoptotic signaling in B-ALL in vitro and in vivo

Abstract Background Casein kinase II (CK2) is involved in multiple tumor-relevant signaling pathways affecting proliferation and apoptosis. CK2 is frequently upregulated in acute B-lymphoblastic leukemia (B-ALL) and can be targeted by the ATP-competitive CK2 inhibitor CX-4945. While reduced prolifer...

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Bibliographic Details

Published in:	BMC Cancer
Main Authors:	Anna Richter, Sina Sender, Annemarie Lenz, Rico Schwarz, Burkhard Hinz, Gudrun Knuebel, Anett Sekora, Hugo Murua Escobar, Christian Junghanss, Catrin Roolf
Format:	Article
Language:	English
Published:	BMC 2020-03-01
Subjects:	B-ALL Apoptosis CK2 CX-4945 BCL6 BACH2
Online Access:	http://link.springer.com/article/10.1186/s12885-020-6650-9