Life’s Essential 8, phenotypic age, and cardiovascular age in prediabetes: predictive value in the UK Biobank and protein mediation in cardiovascular–diabetes comorbidity

Abstract Background Lifestyle improvement may help reverse prediabetes. Indicators such as Life’s Essential 8 (LE8) and biological aging measures (phenotypic age, cardiovascular biological age) partially reflect metabolic status in prediabetes, but their predictive value for cardiovascular mortality...

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Bibliographic Details

Published in:	European Journal of Medical Research
Main Authors:	Chaoping Chen, Chenhao Li, Qingru Zhu, Yang Yang, Sixiang Jia, Xiaojian Zhang, Shudong Xia
Format:	Article
Language:	English
Published:	BMC 2025-10-01
Online Access:	https://doi.org/10.1186/s40001-025-03218-7