Chronic Lymphocytic Leukemia (CLL)-Derived Extracellular Vesicles Educate Endothelial Cells to Become IL-6-Producing, CLL-Supportive Cells

We hypothesized that via extracellular vesicles (EVs), chronic lymphocytic leukemia (CLL) cells turn endothelial cells into CLL-supportive cells. To test this, we treated vein-derived (HUVECs) and artery-derived (HAOECs) endothelial cells with EVs isolated from the peripheral blood of 45 treatment-n...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Orit Uziel, Lian Lipshtein, Zinab Sarsor, Einat Beery, Shaked Bogen, Meir Lahav, Alon Regev, Vitali Kliminski, Roded Sharan, Asia Gervits, Lorenzo Federico Signorini, Shai Shimony, Pia Raanani, Uri Rozovski
Format:	Article
Language:	English
Published:	MDPI AG 2024-06-01
Subjects:	CLL EVs endothelial cells
Online Access:	https://www.mdpi.com/2227-9059/12/7/1381