Secreted AZGP1 induced by 5-FU binds to PD-L1 and promotes apoptosis in cholangiocarcinoma

Abstract Background Cholangiocarcinoma (CCA) is an aggressive malignancy with limited treatment options and poor clinical outcomes. The identification of predictive biomarkers that can enhance chemotherapy efficacy and inform immune modulation remains an urgent unmet need. Methods We investigated th...

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Bibliographic Details
Published in:Molecular Medicine
Main Authors: Ji-Eun You, Do Yeon Kim, Hyeseon Yun, Dong-In Koh, Yea Seong Ryu, Dong-Hoon Jin
Format: Article
Language:English
Published: BMC 2025-09-01
Subjects:
Cholangiocarcinoma
Soluble AZGP1
PD-L1
5-FU
Online Access:https://doi.org/10.1186/s10020-025-01362-8

Internet

https://doi.org/10.1186/s10020-025-01362-8

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