Decoding TDP-43: the molecular chameleon of neurodegenerative diseases

Abstract TAR DNA-binding protein 43 (TDP-43) has emerged as a critical player in neurodegenerative disorders, with its dysfunction implicated in a wide spectrum of diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and Alzheimer’s disease (AD). This com...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Jixiang Zeng, Chunmei Luo, Yang Jiang, Tao Hu, Bixia Lin, Yuanfang Xie, Jiao Lan, Jifei Miao
Format:	Article
Language:	English
Published:	BMC 2024-12-01
Subjects:	TDP-43 neurodegeneration RNA metabolism chromatin regulation cryptic exons mitochondrial dysfunction
Online Access:	https://doi.org/10.1186/s40478-024-01914-9