Advances in strategies to improve the immunotherapeutic efficacy of chimeric antigen receptor-T cell therapy for lymphoma

Chimeric antigen receptor-T (CAR-T) cell therapy is a precise immunotherapy for lymphoma. However, its long-term efficacy faces many challenges related to tumor cell heterogeneity, interference from immunosuppressive microenvironments, CAR-T cell exhaustion, and unmanageable adverse events. Diverse...

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Bibliographic Details

Published in:	Cancer Biology & Medicine
Main Authors:	Tianshu Yu, Xianhuo Wang, Ou Bai, Huilai Zhang, Wenbin Qian
Format:	Article
Language:	English
Published:	China Anti-Cancer Association 2025-04-01
Subjects:	chimeric antigen receptor-t cell lymphoma cytotherapy immunotherapy epigenetics metabolism
Online Access:	https://www.cancerbiomed.org/content/22/4/301