Development of Self-Associating SN-38-Conjugated Poly(ethylene oxide)-Poly(ester) Micelles for Colorectal Cancer Therapy

The clinical use of 7-ethyl-10-hydroxy-camptothecin (SN-38), which is the active metabolite of irinotecan, has been hampered because of its practical water-insolubility. In this study, we successfully synthesized two self-associating SN-38-polymer drug conjugates to improve the water-solubility of S...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Sams M. A. Sadat, Mohammad Reza Vakili, Igor M. Paiva, Michael Weinfeld, Afsaneh Lavasanifar
Format:	Article
Language:	English
Published:	MDPI AG 2020-10-01
Subjects:	SN-38 irinotecan chemotherapy polymeric micelle colorectal cancer mPEO-<i>b</i>-PBCL
Online Access:	https://www.mdpi.com/1999-4923/12/11/1033