KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis

Abstract: KDM2B together with RING1B, PCGF1, and BCOR or BCORL1 comprise polycomb repressive complex 1.1 (PRC1.1), a noncanonical PRC1 that catalyzes H2AK119ub1. It binds to nonmethylated CpG islands through its zinc finger-CxxC DNA binding domain and recruits the complex to target gene loci. Recent...

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Bibliographic Details

Published in:	Blood Advances
Main Authors:	Yusuke Isshiki, Yaeko Nakajima-Takagi, Motohiko Oshima, Kazumasa Aoyama, Mohamed Rizk, Shuhei Kurosawa, Atsunori Saraya, Takashi Kondo, Emiko Sakaida, Chiaki Nakaseko, Koutaro Yokote, Haruhiko Koseki, Atsushi Iwama
Format:	Article
Language:	English
Published:	Elsevier 2019-09-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2473952920300033