Narrative review of rationale for IV deferoxamine plus intranasal insulin to ameliorate brain damage following resuscitation from cardiac arrest

Patients with out of hospital cardiac arrest suffer brain ischemia, and many die from brain injury despite cardiac resuscitation. Upon brain reperfusion molecular mechanisms of neuronal injury are amplified by iron toxicity, activated proteases, and inhibited protein synthesis. This narrative review...

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Bibliographic Details

Published in:	Resuscitation Plus
Main Authors:	Blaine C. White, Jonathon M. Sullivan, James H. Paxton, Thomas H. Sanderson, Joseph M. Wider, Anthony T. Lagina, Brian J. O’Neil
Format:	Article
Language:	English
Published:	Elsevier 2026-05-01
Subjects:	Cardiac resuscitation Brain ischemia Calcium Reperfusion Ferroptosis 4-Hydroxy-nonenal
Online Access:	http://www.sciencedirect.com/science/article/pii/S266652042600130X