Increased Gene Expression Leads to Massive Microglial Cell Activation and Inflammation Throughout the Brain

PMD (Pelizaeus-Merzbacher disease) is a rare neurodegenerative disorder that impairs motor and cognitive functions and is associated with a shortened lifespan. The cause of PMD is mutations of the PLP1 [proteolipid protein 1 gene (human)] gene. Transgenic mice with increased Plp1 [proteolipid protei...

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Bibliographic Details

Published in:	ASN Neuro
Main Authors:	Carrie L Tatar, Sunita Appikatla, Denise A Bessert, Ajaib S Paintlia, Inderjit Singh, Robert P Skoff
Format:	Article
Language:	English
Published:	Taylor & Francis 2010-08-01
Online Access:	https://doi.org/10.1042/AN20100016