Sustained capillary enlargement induced by angiogenic gene therapy does not support post-ischemic muscle recovery of hyperlipidemic mice

BackgroundHyperlipidemia is known to impair endothelial function. We have recently shown that hyperlipidemia also blunts native post-ischemic capillary enlargement that is important for efficient skeletal muscle recovery from ischemia as it supports the recovery of arterial driving pressure and thro...

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Bibliographic Details

Published in:	Frontiers in Bioengineering and Biotechnology
Main Authors:	Galina Wirth, Greta Juusola, Hanne Laakso, Nihay Laham-Karam, Seppo Ylä-Herttuala, Petra Korpisalo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Subjects:	hyperlipidemia ischemia adenovirus VEGF gene therapy capillary enlargement
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2025.1512962/full