Loss of PIKfyve drives the spongiform degeneration in prion diseases

Abstract Brain‐matter vacuolation is a defining trait of all prion diseases, yet its cause is unknown. Here, we report that prion infection and prion‐mimetic antibodies deplete the phosphoinositide kinase PIKfyve—which controls endolysosomal maturation—from mouse brains, cultured cells, organotypic...

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Bibliographic Details

Published in:	EMBO Molecular Medicine
Main Authors:	Asvin K K Lakkaraju, Karl Frontzek, Emina Lemes, Uli Herrmann, Marco Losa, Rajlakshmi Marpakwar, Adriano Aguzzi
Format:	Article
Language:	English
Published:	Springer Nature 2021-07-01
Subjects:	neurodegeneration palmitoylation prion spongiosis unfolded protein response
Online Access:	https://doi.org/10.15252/emmm.202114714