Finerenone Alleviates Over-Activation of Complement C5a-C5aR1 Axis of Macrophages by Regulating G Protein Subunit Alpha i2 to Improve Diabetic Nephropathy

Diabetic nephropathy (DN), one of the most common complications of diabetes mellitus (DM), accounts for a major cause of chronic kidney disease (CKD) worldwide, with a complicated pathogenesis and limited effective strategies nowadays. The mineralocorticoid receptor (MR) is a classical ligand-activa...

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Bibliographic Details

Published in:	Cells
Main Authors:	Zi-Han Li, Zi-Jun Sun, Sydney C. W. Tang, Ming-Hui Zhao, Min Chen, Dong-Yuan Chang
Format:	Article
Language:	English
Published:	MDPI AG 2025-02-01
Subjects:	diabetic nephropathy finerenone MR C5aR1 Gn?i2
Online Access:	https://www.mdpi.com/2073-4409/14/5/337