Prediction of Antibody Viscosity from Dilute Solution Measurements

The high antibody doses required to achieve a therapeutic effect often necessitate high-concentration products that can lead to challenging viscosity issues in production and delivery. Predicting antibody viscosity in early development can play a pivotal role in reducing late-stage development costs...

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Bibliographic Details

Published in:	Antibodies
Main Authors:	Kamal Bhandari, Yangjie Wei, Brendan R. Amer, Emma M. Pelegri-O’Day, Joon Huh, Jeremy D. Schmit
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Subjects:	viscosity binding affinity reptation affinity-capture self-interaction nanoparticle spectroscopy (AC-SINS) dynamic light scattering (DLS)
Online Access:	https://www.mdpi.com/2073-4468/12/4/78