First steps in the development of an ovine proximal phalanx fracture and bone defect model: a study of animal welfare and bone healing

There is a need for large-animal fracture models focusing on small tubular bones, as existing models typically involve major weight-bearing bones and often rely on restrictive suspension systems that raise significant animal welfare concerns. This study presents a novel in vivo sheep model targeting...

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Bibliographic Details

Published in:	Frontiers in Veterinary Science
Main Authors:	Nanett Kvist Nikolaisen, Thomas Colding-Rasmussen, Peter F. Horstmann, Anna V. Müller, José Joaquín Cerón, Michael Mørk Petersen, Christian Nai En Tierp-Wong, Stine Jacobsen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	biomarkers bone healing large animal model pain scores sheep small tubular bones
Online Access:	https://www.frontiersin.org/articles/10.3389/fvets.2025.1662553/full