Personalizing voriconazole dosing in Chinese hematological patients: CYP2C19 phenotype and albumin-bilirubin grade as key predictors of trough concentrations

PurposeThis retrospective, single-center study aimed to evaluate the genetic and non-genetic factors influencing voriconazole (VRC) trough concentration (Ctrough), efficacy and safety in hematological patients.MethodsMedical records of inpatients were reviewed retrospectively. Univariate and multiva...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Lin Hu, Xi Tang, Yanfei Li, Juanjuan Huang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	voriconazole CYP2C19 phenotype albumin-bilirubin grade hematological patients therapeutic drug monitoring
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1667461/full