Sulbactam-durlobactam improves cephalosporin and carbapenem susceptibility and time-kill effect against Mycobacterium abscessus

ABSTRACT Despite the long therapy duration, the treatment outcomes for Mycobacterium abscessus lung disease (MAB-LD) are very poor. β-Lactams are among the recommended drugs for the treatment of MAB-LD; however, they are prone to hydrolysis by MAB β-lactamase enzymes. Therefore, β-lactamase inhibito...

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Bibliographic Details
Published in:Microbiology Spectrum
Main Authors: Avneesh Shrivastava, Gunavanthi D. Boorgula, Sanjay Singh, Danaleigh Stiles, Pamela J. McShane, Megan Devine, Tawanda Gumbo, Shashikant Srivastava
Format: Article
Language:English
Published: American Society for Microbiology 2025-10-01
Subjects:
cephalosporins
carbapenems
MIC
nontuberculous mycobacteria
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01492-25

Internet

https://journals.asm.org/doi/10.1128/spectrum.01492-25

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