Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades. Previously, we have found that soluble collectin-12 (sCL-12) synergizes complement alternative pathway (AP) activation. However, wheth...

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Bibliographic Details

Published in:	eLife
Main Authors:	Jie Zhang, Lihong Song, Dennis V Pedersen, Anna Li, John D Lambris, Gregers Rom Andersen, Tom Eirik Mollnes, Ying Jie Ma, Peter Garred
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-09-01
Subjects:	collectin-12 properdin alternative pathway the complement system
Online Access:	https://elifesciences.org/articles/60908