Vacuolar Protein Sorting genes in Parkinson’s Disease: a re-appraisal of mutations detection rate and neurobiology of disease

Mammalian retromers play a critical role in protein trans-membrane sorting from endosome to the trans-Golgi network (TGN). Recently, retromers have been linked to Parkinson's Disease (PD) since the identification of the variant p.Asp620Asn in VPS35 (Vacuolar Protein Sorting 35) as a cause of...

Full description

Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Stefano Gambardella, Francesca Biagioni, Rosangela Ferese, Carla Letizia Busceti, Alessandro Frati, Giuseppe Novelli, Stefano Ruggieri, Francesco Fornai
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-11-01
Subjects:	Neurogenetics Protein Clearance VPS Autophagoproteasome Genetic Parkinsonism
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00532/full