Dual-Uptake Mode of the Antibiotic Phazolicin Prevents Resistance Acquisition by Gram-Negative Bacteria

ABSTRACT Phazolicin (PHZ) is a peptide antibiotic exhibiting narrow-spectrum activity against rhizobia closely related to its producer, Rhizobium sp. strain Pop5. Here, we show that the frequency of spontaneous PHZ-resistant mutants in Sinorhizobium meliloti is below the detection limit. We find tha...

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Bibliographic Details

Published in:	mBio
Main Authors:	Dmitrii Y. Travin, Romain Jouan, Armelle Vigouroux, Satomi Inaba-Inoue, Joy Lachat, Fazal Haq, Tatiana Timchenko, Dmitry Sutormin, Svetlana Dubiley, Konstantinos Beis, Solange Moréra, Konstantin Severinov, Peter Mergaert
Format:	Article
Language:	English
Published:	American Society for Microbiology 2023-04-01
Subjects:	phazolicin antimicrobial peptides ABC importers SLiPT substrate-binding protein RiPP uptake
Online Access:	https://journals.asm.org/doi/10.1128/mbio.00217-23