Endothelial Specific Deletion of Autotaxin Improves Stroke Outcomes

Autotaxin (ATX) is an extracellular secretory enzyme (lysophospholipase D) that catalyzes the hydrolysis of lysophosphatidyl choline to lysophosphatidic acid (LPA). The ATX–LPA axis is a well-known pathological mediator of liver fibrosis, metastasis in cancer, pulmonary fibrosis, atherosclerosis, an...

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Bibliographic Details

Published in:	Cells
Main Authors:	Susmita Bhattarai, Utsab Subedi, Shrivats Manikandan, Sudha Sharma, Papori Sharma, Chloe Miller, Md Shenuarin Bhuiyan, Srivatsan Kidambi, Vassilis Aidinis, Hong Sun, Sumitra Miriyala, Manikandan Panchatcharam
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Subjects:	autotaxin (ATX) lysophosphatidic acid (LPA) ischemic stroke endothelium permeability
Online Access:	https://www.mdpi.com/2073-4409/12/3/511