FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

Abstract Tau aggregation into amyloid fibers based on the cross-beta structure is a hallmark of several Tauopathies, including Alzheimer Disease (AD). Trans-cellular propagation of Tau with pathological conformation has been suggested as a key disease mechanism. This is thought to cause the spreadin...

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Bibliographic Details

Published in:	Molecular Neurodegeneration
Main Authors:	Senthilvelrajan Kaniyappan, Katharina Tepper, Jacek Biernat, Ram Reddy Chandupatla, Sabrina Hübschmann, Stephan Irsen, Sandra Bicher, Christoph Klatt, Eva-Maria Mandelkow, Eckhard Mandelkow
Format:	Article
Language:	English
Published:	BMC 2020-07-01
Subjects:	Tau protein Propagation Seeding Alzheimer Amyloid
Online Access:	http://link.springer.com/article/10.1186/s13024-020-00389-1