Single-Cell Transcriptomics of Human Tonsils Reveals Nicotine Enhances HIV-1-Induced NLRP3 Inflammasome and Mitochondrial Activation

Background: HIV-1 infection, even with effective antiretroviral therapy (ART), is associated with chronic inflammation and immune dysfunction, contributing to long-term health complications. Nicotine use, prevalent among people with HIV (PWH), is known to exacerbate immune activation and disease pro...

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Bibliographic Details

Published in:	Viruses
Main Authors:	Nadine Schrode, Trinisia Fortune, Aislinn M. Keane, Jesse F. Mangold, Benjamin Tweel, Kristin G. Beaumont, Talia H. Swartz
Format:	Article
Language:	English
Published:	MDPI AG 2024-11-01
Subjects:	HIV-1 nicotine NLRP3 inflammasome oxidative stress mitochondrial dysfunction
Online Access:	https://www.mdpi.com/1999-4915/16/11/1797